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Excretion of oral 9-cis-retinoic acid in the rat
1Laboratoire de Toxicologie et Pharmacie Clinique, Faculté de Pharmacie, Marseille, France.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|November 1, 1996
Abstract:
We have studied excretion of oral 9-cis-retinoic acid in urine and feces in vigil rats and in bile in anesthetized rats. A proportion of 53 +/- 13% of the dose of 9-cis-retinoic acid administered was eliminated through the feces in 72 hr, and the urinary excretion was negligible. The prevalent form of elimination in feces and urine was the unchanged compound. Low biliary excretion was, for the most part, composed of metabolites.