Psychological and cognitive status before and after heart transplantation

Advances in the technical aspects of heart transplantation and the medical management of rejection have allowed a shift toward research evaluating psychological factors affecting heart transplant candidates and psychosocial sequelae following transplantation. This study examined the psychological and cognitive status of patients presenting for heart transplant evaluation. The findings indicated that this patient group was characterized by impaired verbal memory and a tendency toward depression and anxiety. The second part of the study examined changes in psychological and cognitive status from the initial evaluation to a follow-up assessment 1 year after transplantation. The results indicated that psychological distress (depression, anxiety) and several indices of cognitive function improved after transplantation. Finally, correlations were determined to evaluate the association between the psychological and cognitive measures and episodes of rejection in the first 6 months after transplantation. Anxiety, depression, and a nonverbal measure of intelligence were found to be associated with the number of episodes of rejection. The implications of these findings are discussed.