Vulnerability to depression: a model centered on anhedonia
Related Experiment Video
Updated: Oct 2, 2026

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
Published on: October 24, 2018
1Service Hospitalo-Universitaire de Psychiatrie, Hopital Pinel, Amiens, France.
Abstract:
The aim of the present study is to present a model of depressive vulnerability centered on anhedonia. After a review of the literature, we suggest a specific symptomatic profile associating anhedonia, introversion, low sensation-seeking, autonomy, dysfunctional attitudes, high displeasure capacity, obsessive-compulsive features, passitivity and pessimism. This symptomatic profile could constitute a mild chronic mood disorder which, following stress, might decompensate into unipolar endogenomorphic depression. Several methods of research are suggested to test the validity of our model.
Related Concept Videos
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Depression: Overview
Depressive Disorders: MDD and Dysthymia
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

