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Lead: intestinal absorption and bone mobilization during lactation

M Maldonado-Vega1, J Cerbón-Solorzano, A Albores-Medina

  • 1Department of Biochemistry, CINVESTAV-IPN, México City, México.

Human & Experimental Toxicology
|November 1, 1996
PubMed
Summary

Maternal lead exposure leads to bone lead stores that mobilize during lactation, increasing blood lead and transferring to pups. This highlights bone lead resorption as a significant source of lead toxicity during nursing.

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Area of Science:

  • Toxicology
  • Environmental Health
  • Reproductive Biology

Background:

  • Chronic lead exposure in pregnant and lactating animals poses risks to both mothers and offspring.
  • Lead accumulation in maternal bone serves as a reservoir for later redistribution.
  • Lactation is a critical period for potential lead transfer from mother to neonate.

Purpose of the Study:

  • To investigate lead (Pb) intestinal absorption, mobilization, and redistribution during lactation in rats with chronic lead exposure.
  • To quantify lead and calcium concentrations in blood, milk, bone, liver, and kidney.
  • To differentiate sources of lead exposure and redistribution during different lactation phases.

Main Methods:

  • Rats were exposed to lead (Pb) for varying durations before and during lactation.

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  • Lead and calcium levels were measured in blood, milk, femurs, liver, and kidney.
  • Results were compared between exposed groups and non-exposed controls.

    • Main Results:

    • During lactation, lead in blood, liver, and kidney increased while bone lead decreased in chronically exposed rats.
    • Bone lead resorption was identified as a primary source of lead redistribution during lactation in the absence of external exposure.
    • Maternal lead exposure leads to increased blood lead levels via intestinal absorption and bone deposition/resorption processes.

    Conclusions:

    • Lead stored in maternal bone from prior exposure is a major source of self-intoxication.
    • Mobilized bone lead contributes significantly to lead transfer into milk, posing a risk to suckling pups.
    • Understanding lead dynamics during lactation is crucial for mitigating developmental toxicity.