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HLA genotypes and the increased incidence of coeliac disease in Sweden

R Ploski1, H Ascher, L M Sollid

  • 1Institute of Transplantation Immunology, National Hospital, University of Oslo, Norway.

Scandinavian Journal of Gastroenterology
|November 1, 1996
PubMed

Insights

The rise in childhood coeliac disease (CD) in Sweden is not linked to individuals with less predisposing HLA genotypes. Genetic susceptibility in Swedish CD patients appears similar to other populations.

Area of Science:

  • Immunogenetics
  • Pediatric Gastroenterology

Background:

  • Childhood coeliac disease (CD) incidence has risen in Sweden.
  • This increase coincided with changes in infant feeding practices.

Purpose of the Study:

  • To investigate if the CD increase in Sweden is due to individuals with less predisposing Human Leukocyte Antigen (HLA) genotypes.
  • To compare HLA class-II genotypes between Swedish CD patients and controls.

Main Methods:

  • Genomic HLA-DRB1, -DQA1, and -DQB1 typing was conducted.
  • 135 Swedish CD patients (low- and high-incidence cohorts) and 179 controls were analyzed.
  • Distribution of HLA class-II genotypes was compared across cohorts.

Main Results:

  • Specific HLA genotypes (DQA1*0501 and DQB1*02) were associated with increased CD risk.
  • A gene dosage effect for DQB1*02 was observed.
  • No significant difference in HLA genotype distribution was found between the cohorts.

Conclusions:

  • Swedish coeliac disease patients exhibit similar genetic susceptibility to other populations.
  • The observed increase in CD is unlikely due to a higher prevalence of less predisposing HLA genotypes.
Abstract

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