Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA-DQA1 subtyping data in the Swiss population

C Gehrig1, M N Hochmeister, B Budowle

  • 1Institute of Legal Medicine, University of Bern, Switzerland.

Forensic Science International
|November 11, 1996
PubMed
Summary

This study refined human leukocyte antigen DQA1 (HLA-DQA1) allele frequencies in a Swiss population by subtyping the 4 allele. This enhanced genetic marker data improves forensic analysis accuracy in this demographic.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

4th DNA Forensic Symposium: Challenges and future directions in Africa.

Forensic science international. Synergy·2024
Same author

Association of whole mtDNA, an NADPH G11914A variant, and haplogroups with high physical performance in an elite military troop.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2021
Same author

Evaluation of InnoTyper® 21 in a sample of Rio de Janeiro population as an alternative forensic panel.

International journal of legal medicine·2017
Same author

Letter to the editor: Are the doors opened to a genetic-based algorithm for personalized resistance training?

Biology of sport·2017
Same author

Global genetic variation of select opiate metabolism genes in self-reported healthy individuals.

The pharmacogenomics journal·2017
Same author

No evidence for the presence of genetic variants predisposing to psychotic disorders on the non-deleted 22q11.2 allele of VCFS patients.

Translational psychiatry·2017

Area of Science:

  • Forensic Genetics
  • Population Genetics
  • Molecular Biology

Background:

  • Previous studies established DNA genetic marker HLA-DQA1 allele and genotype frequencies in a Swiss population (n=200).
  • The HLA-DQA1 locus is a valuable tool in forensic genetic analyses due to its discriminatory power.

Purpose of the Study:

  • To subtype the HLA-DQA1 allele 4 in a Swiss Caucasian population sample.
  • To enhance the discriminatory power of the HLA-DQA1 locus for forensic applications in Switzerland.

Main Methods:

  • Utilized the AmpliType PM+ DQA1 PCR Amplification and Typing Kit for allele subtyping.
  • Analyzed allele and genotype frequencies in a Swiss Caucasian population sample (n=200).
  • Assessed deviations from Hardy-Weinberg equilibrium.

Related Experiment Videos

Main Results:

  • Successfully distinguished HLA-DQA1 allele 4.1 from 4.2 and 4.3.
  • Observed no deviations from Hardy-Weinberg equilibrium.
  • The power of discrimination (Pd) for HLA-DQA1 increased from 0.931 to 0.938 with the subtyping of allele 4.

Conclusions:

  • Subtyping the HLA-DQA1 allele 4 refines genetic profiles for the Swiss population.
  • The updated frequency data enhances the accuracy of HLA-DQA1 profile estimations in forensic casework.
  • This detailed genetic information is crucial for robust forensic investigations.