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Related Experiment Videos

T-cell gene therapy

K M Hege1, M R Roberts

  • 1Cell Genesys Inc, 322 Lakeside Drive, Foster City, CA 94404, USA. hege_kristen@cellgenesys.com

Current Opinion in Biotechnology
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Human gene therapy trials are advancing, focusing on T lymphocytes for treating severe combined immunodeficiency syndrome, HIV, and cancers. These studies explore gene transfer and novel T-cell receptors for enhanced therapeutic efficacy.

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Area of Science:

  • Immunology
  • Genetics
  • Oncology

Background:

  • Gene therapy using T lymphocytes is a rapidly evolving field.
  • Recent advancements include trials for various genetic disorders and infectious diseases.

Purpose of the Study:

  • To review current human gene therapy trials involving T lymphocytes.
  • To highlight diverse therapeutic strategies and targets.

Main Methods:

  • Adoptive transfer of genetically modified T lymphocytes.
  • Gene transfer for adenosine deaminase deficiency.
  • Gene marking of Epstein-Barr virus-specific cytotoxic T cells.
  • Engineering T-cell receptors for antigen specificity.

Main Results:

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  • Successful trials reported for severe combined immunodeficiency syndrome and HIV.
  • Gene-modified T cells show promise in targeting viral infections and malignancies.
  • Novel T-cell receptor engineering is under investigation.

    • Conclusions:

    • T-cell gene therapy offers a promising avenue for treating a range of diseases.
    • Ongoing research focuses on improving specificity and safety of gene-modified T cells.