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A structural explanation for the twilight zone of protein sequence homology
1Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. schung@usuhsb.usuhs.mil
Structure (London, England : 1993)
|October 15, 1996
Abstract:
Homology modeling of protein structures as a function of sequence breaks down at the twilight zone limit of sequence identity between the template and target proteins. Our results suggest that protein sequences that have diverged from a common ancestor beyond the twilight zone may adopt side-chain interactions that are very different from those endowed by the ancestral sequence.