Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How proteolysis drives the cell cycle

R W King1, R J Deshaies, J M Peters

  • 1Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.

Science (New York, N.Y.)
|December 6, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recurrence quantification analysis of resting state EEG signals in autism spectrum disorder - a systematic methodological exploration of technical and demographic confounders in the search for biomarkers.

BMC medicine·2018
Same author

Neurophysiological evidence of preserved connectivity in tuber tissue.

Epilepsy & behavior case reports·2017
Same author

COMBINED DELAY AND GRAPH EMBEDDING OF EPILEPTIC DISCHARGES IN EEG REVEALS COMPLEX AND RECURRENT NONLINEAR DYNAMICS.

Proceedings. IEEE International Symposium on Biomedical Imaging·2015
Same author

PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling.

Oncogene·2013
Same author

Early thalamic lesions in patients with sleep-potentiated epileptiform activity.

Neurology·2012
Same author

Diabetic retinopathy screening: perspectives of people with diabetes, screening intervals and costs of attending screening.

Diabetic medicine : a journal of the British Diabetic Association·2012

Proteolysis, the breakdown of proteins, drives cell cycle progression by regulating cyclin-dependent kinases (CDKs) and triggering key transitions like the switch from metaphase to anaphase. This process involves specific ubiquitin pathways essential for DNA replication and chromosome segregation.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cyclin-dependent kinases (CDKs) exhibit oscillations crucial for eukaryotic cell cycle progression.
  • Proteolysis, the regulated degradation of proteins, plays a significant role in controlling cell cycle events.

Purpose of the Study:

  • To review the mechanisms by which proteolysis regulates CDK activity.
  • To examine the role of proteolysis in triggering the metaphase-to-anaphase transition.
  • To explore how proteolysis influences chromosome and spindle dynamics.

Main Methods:

  • Review of existing literature on cell cycle regulation and proteolysis.
  • Analysis of ubiquitin-conjugation pathways involved in cell cycle control.

Related Experiment Videos

Main Results:

  • Proteolysis regulates CDK activity by degrading CDK activators and inhibitors.
  • Two ubiquitin-conjugation pathways mediate proteolysis during the cell cycle: one involving CDC34 for DNA replication, and the anaphase-promoting complex/cyclosome for chromosome segregation and mitotic exit.
  • Proteolysis directly triggers the metaphase-to-anaphase transition.

Conclusions:

  • Proteolysis is a key driver of cell cycle progression.
  • Proteolysis regulates CDK activity and directly influences chromosome and spindle dynamics.
  • Ubiquitin-conjugation pathways are central to proteolysis-mediated cell cycle control.