Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human apolipoprotein E: the Alzheimer's disease connection

K H Weisgraber1, R W Mahley

  • 1Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, 94141-9100, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|November 1, 1996
PubMed
Summary

Apolipoprotein E (apoE) is a key genetic risk factor for Alzheimer's disease. The apoE4 allele is more common in Alzheimer's patients, suggesting it impairs neuronal repair.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.

Acta neurologica Scandinavica. Supplementum·2006
Same author

Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).

The pharmacogenomics journal·2006
Same author

An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks.

Clinical genetics·2005
Same author

DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women.

Clinical genetics·2002
Same author

Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle.

Neurology·2002
Same author

Plasma lipids in Turkish children: impact of puberty, socioeconomic status, and nutrition on plasma cholesterol and HDL.

Journal of lipid research·2001

Area of Science:

  • Neuroscience
  • Genetics
  • Biochemistry

Background:

  • Apolipoprotein E (apoE) is crucial for cholesterol transport and lipoprotein metabolism.
  • Recent evidence identifies apoE as a significant genetic risk factor for Alzheimer's disease (AD).
  • The apoE4 allele is disproportionately found in AD patients compared to controls.

Purpose of the Study:

  • To investigate the role of apolipoprotein E in Alzheimer's disease pathogenesis.
  • To explore how different apoE alleles influence neuronal repair mechanisms.

Main Methods:

  • Genetic and epidemiological analysis of apoE allele frequencies in Alzheimer's subjects.
  • Biochemical and cell biology studies examining apoE structure and function.
  • Comparative analysis of apoE3 and apoE4 in neuronal repair processes.

Related Experiment Videos

Main Results:

  • The apoE4 allele is significantly overrepresented in individuals with Alzheimer's disease.
  • Biochemical and cellular studies provide insights into apoE's involvement in neurodegeneration.
  • ApoE likely plays a role in a common pathway for neuronal repair and remodeling.

Conclusions:

  • Apolipoprotein E is a major susceptibility gene contributing to Alzheimer's disease heterogeneity.
  • The apoE3 allele supports effective neuronal repair after injury.
  • The apoE4 allele appears less effective in supporting neuronal repair and remodeling, potentially contributing to Alzheimer's disease development.