Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropeptide changes in dementia: pathogenetic implications and diagnostic value

G Valenti1

  • 1University of Parma, Italy.

Gerontology
|January 1, 1996
PubMed
Summary

Neuropeptide alterations in the brain and cerebrospinal fluid are linked to Alzheimer's disease and dementia. However, these changes lack the specificity for reliable diagnostic use in elderly patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Physical review letters·2026
Same author

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Physical review letters·2026
Same author

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

Physical review letters·2026
Same author

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Physical review letters·2026
Same author

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

Physical review letters·2026
Same author

First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

Physical review letters·2026

Area of Science:

  • Neuroscience
  • Biochemistry
  • Gerontology

Background:

  • Neuropeptides play crucial roles in brain function.
  • Alzheimer's disease (AD) involves complex neurochemical changes.
  • Understanding neuropeptide involvement in dementia is vital for diagnosis and treatment.

Purpose of the Study:

  • To review significant neuropeptide pattern alterations in the brain and cerebrospinal fluid (CSF) of demented patients, especially those with Alzheimer type dementia (AD).
  • To explore the peripheral endocrine implications of these neuropeptide changes.
  • To assess the role of neuropeptides in the pathogenesis of dementia.

Main Methods:

  • Review of existing literature on neuropeptide alterations in dementia.
  • Analysis of neuropeptide concentration changes in different brain areas and CSF.
  • Examination of peripheral endocrine effects related to neuropeptide dysregulation.

Main Results:

  • Significant alterations in neuropeptide patterns are observed in the brain and CSF of demented individuals, particularly in Alzheimer type dementia.
  • Neuropeptide changes may contribute to dementia pathogenesis, alongside classical neurotransmitter system alterations.
  • Neuropeptide levels in CSF and postmortem brain tissue have yielded controversial results as diagnostic biomarkers.

Conclusions:

  • Neuropeptide alterations in the demented brain exhibit regional differences.
  • These changes are not sufficiently specific or selective to reliably differentiate between various forms of dementia, including senile dementia and Alzheimer type dementia.
  • Further research is needed to clarify the diagnostic utility of neuropeptides in dementia.

Related Experiment Videos