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Related Experiment Videos

Sprayed medicated feed with sulfadimidine for piglets

M Wanner1, K Küng, J L Riond

  • 1Institute of Veterinary Physiology, University of Zürich, Switzerland.

Zentralblatt Fur Veterinarmedizin. Reihe A
|October 1, 1996
PubMed
Summary

Two medicated feed forms containing sulfadimidine (SDM) were bioequivalent and efficacious in piglets. Both spray-dried (SPR) and premix (PMX) feed forms achieved therapeutic SDM levels, with PMX showing slightly higher concentrations, especially with ad libitum feeding.

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Area of Science:

  • Veterinary Pharmacology
  • Animal Nutrition
  • Drug Bioavailability

Background:

  • Sulfadimidine (SDM) is an important antimicrobial agent in swine production.
  • Medicated feed is a common route for SDM administration to piglets.
  • Different feed preparation methods may influence SDM bioavailability.

Purpose of the Study:

  • To compare the bioavailability of two sulfadimidine (SDM) medicated feed formulations in piglets.
  • To evaluate the pharmacokinetic parameters of SDM after intravenous and oral administration.
  • To assess the efficacy of SDM medicated feed under different feeding regimens.

Main Methods:

  • Pharmacokinetic analysis of SDM in piglets following intravenous and oral administration of two feed forms: spray-dried (SPR) and premix (PMX).

Related Experiment Videos

  • Determination of serum SDM concentrations over time under restrictive and ad libitum feeding conditions.
  • In vitro dissolution testing of both medicated feed formulations.

    • Main Results:

    • Intravenous administration yielded a volume of distribution of 0.34 L/kg and elimination half-life of 11.1 h.
    • Oral administration showed slightly higher Cmax and bioavailability with PMX compared to SPR, though not statistically significant.
    • Both SPR and PMX medicated feeds achieved potentially efficacious plasma SDM concentrations (50-150 µg/mL) within 24 hours.
    • Ad libitum feeding resulted in higher SDM intake and more consistent plasma concentrations compared to restrictive feeding.
    • In vitro, SPR showed rapid SDM release (58% in 15 min), while PMX release was slower (3% in 15 min).

    Conclusions:

    • Both SPR and PMX medicated feed formulations are bioequivalent and potentially efficacious for SDM delivery in piglets.
    • Ad libitum feeding enhances SDM absorption and plasma concentration stability.
    • Despite differences in in vitro dissolution rates, in vivo absorption of SDM from both feed forms was satisfactory.