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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Hyperlipidemia and the rheumatic diseases
1Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
Insights
Systemic lupus erythematosus (SLE) can cause early atherosclerosis in children. Dyslipoproteinemia, linked to inflammation and medications, may be a key factor, necessitating early intervention and potential drug therapy.
Area of Science:
- Cardiovascular disease
- Rheumatology
- Pediatric health
Background:
- Premature atherosclerosis is a known complication in systemic lupus erythematosus (SLE).
- Atherosclerosis development starts in childhood, highlighting the need for early preventive strategies.
- Dyslipoproteinemia is a potential contributor, stemming from chronic inflammation or corticosteroid use in SLE patients.
Purpose of the Study:
- To explore the causes of premature atherosclerosis in pediatric SLE.
- To investigate the role of dyslipoproteinemia and anticardiolipin antibodies.
- To discuss potential therapeutic interventions for lipid abnormalities.
Main Methods:
- Review of existing literature on atherosclerosis in pediatric SLE.
- Analysis of the relationship between dyslipoproteinemia, anticardiolipin antibodies, and SLE.
- Evaluation of the efficacy of dietary modifications and fish oil supplementation.
Main Results:
- Dyslipoproteinemia is frequently observed in pediatric SLE patients.
- A link exists between dyslipoproteinemia and anticardiolipin antibodies.
- Dietary changes and fish oil may not fully resolve lipid abnormalities in all patients.
Conclusions:
- Early atherosclerosis is a significant concern in pediatric SLE.
- Dyslipoproteinemia, influenced by inflammation and treatment, is a critical factor.
- Lipid-lowering drugs may be necessary for managing persistent dyslipoproteinemia in this population.
Abstract:
Premature atherosclerosis is a recognized complication of systemic lupus erythematosus. Atherosclerosis begins in the pediatric age group, and interventions directed toward prevention should begin in childhood as well. A possible cause of premature atherosclerosis is dyslipoproteinemia from the underlying chronic inflammatory disease or from corticosteroid therapy. A relationship between dyslipoproteinemia and anticardiolipin antibodies has been demonstrated. Dietary therapy is helpful, but many patients continue to have significant dyslipoproteinemia after both dietary modification and fish oil supplementation. Lipid-lowering drugs may be indicated in this subgroup. Potential mechanisms of dyslipoproteinemia are discussed.
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