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Published on: March 1, 2024
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Psoriatic arthritis in children
Current Opinion in Rheumatology
|September 1, 1996
Summary
Juvenile psoriatic arthritis (JPsA) is a distinct disease, affecting 2-4% of children with chronic arthritis. Early aggressive therapy is recommended for those with symmetric polyarthritis to prevent severe disability.
Area of Science:
- Pediatric Rheumatology
- Immunodermatology
- Genetics
Background:
- Juvenile psoriatic arthritis (JPsA) is recognized as a distinct disease entity.
- It occurs in 2-4% of children with chronic arthritis, with a higher incidence than expected by chance.
- A family history of psoriasis is present in half of JPsA patients, suggesting a genetic predisposition.
Purpose of the Study:
- To characterize the clinical and genetic features of juvenile psoriatic arthritis.
- To delineate the disease subsets and compare their frequencies with juvenile chronic arthritis.
- To inform therapeutic strategies based on disease presentation.
Main Methods:
- Review of existing literature and clinical data on JPsA.
- Analysis of disease patterns, including joint involvement and extra-articular manifestations.
- Examination of genetic associations, including family history and HLA typing.
Main Results:
- JPsA exhibits a typical joint pattern with asymmetric arthritis and a high rate of dactylitis.
- Disease subsets resemble juvenile chronic arthritis but with different frequencies; oligoarticular courses are most common.
- Systemic manifestations are rare in JPsA.
- No consistent Human Leukocyte Antigen (HLA) associations have been identified.
Conclusions:
- Juvenile psoriatic arthritis is a unique disease entity with specific clinical characteristics.
- Oligoarticular JPsA is common, while systemic disease is rare.
- Aggressive early treatment is crucial for children presenting with symmetric polyarthritis to mitigate the risk of severe, disabling outcomes.
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