Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal lupus

J P Buyon1

  • 1Hospital for Joint Diseases, New York University School of Medicine, NY 10003, USA.

Current Opinion in Rheumatology
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Neonatal lupus research reveals specific autoantibodies in mothers and identifies a critical gestational window for fetal heart block. Current treatments show limited success for established heart block, emphasizing the need for further research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Salivary dysbiosis and the clinical spectrum in anti-Ro positive mothers of children with neonatal lupus.

Journal of autoimmunity·2019
Same author

Keeping upbeat to prevent the heartbreak of anti-Ro/SSA pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019
Same author

Autoimmune congenital heart block: complex and unusual situations.

Lupus·2016
Same author

Efficacy and safety of subcutaneous tabalumab, a monoclonal antibody to B-cell activating factor, in patients with systemic lupus erythematosus: results from ILLUMINATE-2, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study.

Annals of the rheumatic diseases·2015
Same author

Anti-C1q antibodies in systemic lupus erythematosus.

Lupus·2014
Same author

Discordant spectrum of cardiac manifestations of neonatal lupus in twins.

Lupus·2011
Same journal

New approaches to the management of cutaneous lupus.

Current opinion in rheumatology·2026
Same journal

"Updates in chronic nonbacterial osteomyelitis: emerging insights across the age spectrum".

Current opinion in rheumatology·2026
Same journal

Difficult-to-treat, complex-to-manage, treatment-refractory spondyloarthritis: semantics or substance?

Current opinion in rheumatology·2026
Same journal

Update on IgA nephropathy: implications for treatment in IgA vasculitis: a guide for rheumatologists.

Current opinion in rheumatology·2026
Same journal

Polyarticular juvenile idiopathic arthritis: insights from genetic studies on disease risk and pathogenesis.

Current opinion in rheumatology·2026
Same journal

Immune dysregulation in children with Down syndrome: clinical implications and emerging therapies.

Current opinion in rheumatology·2026
See all related articles

Area of Science:

  • Reproductive immunology
  • Pediatric cardiology
  • Autoimmune diseases

Background:

  • Neonatal lupus is a rare condition offering insights into autoimmune disease mechanisms.
  • Fetal heart block, a key manifestation, typically occurs between 16 and 24 weeks of gestation.
  • Research explores autoantigens (SSA/Ro-SSB/La, p57, retrovirus-3, laminin) in affected fetal and adult hearts.

Purpose of the Study:

  • To review recent clinical and basic research advancements in neonatal lupus.
  • To identify maternal autoantibody profiles associated with neonatal lupus.
  • To evaluate current and potential therapeutic strategies for fetal heart block.

Main Methods:

  • Analysis of clinical case studies and basic science investigations.
  • Examination of autoantigen expression in fetal and adult cardiac tissue.

Related Experiment Videos

  • Review of maternal autoantibody testing (ELISA, immunoblot) and immunogenetic associations.

    • Main Results:

    • Anti-52-kD autoantibodies are nearly universal in mothers of infants with neonatal lupus.
    • Anti-U1RNP antibodies without anti-SSA/Ro-SSB/La are linked to isolated cutaneous neonatal lupus.
    • Dexamethasone reduces effusions but does not reverse established third-degree heart block; sympathomimetics may aid hydropic fetuses.

    Conclusions:

    • Maternal autoantibody profiles are not yet definitively unique for neonatal lupus.
    • Immunogenetics suggest a closer link to Sjögren's syndrome than systemic lupus erythematosus.
    • Established heart block remains challenging to treat; prophylactic therapies lack evidence beyond monitoring.