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Related Experiment Videos

FGF induces new feather buds from developing avian skin

R B Widelitz1, T X Jiang, A Noveen

  • 1Department of Pathology, University of Southern California, Los Angeles 90033, USA.

The Journal of Investigative Dermatology
|December 1, 1996
PubMed
Summary

Fibroblast growth factors (FGFs) promote skin appendage formation. FGFs induce new feather buds and expand existing feather bud domains in developing chicken skin, highlighting their role in skin morphogenesis.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Dermatology

Background:

  • Skin appendage formation is a complex process involving molecular signaling.
  • Fibroblast growth factors (FGFs) are key peptide growth factors regulating cell proliferation and morphogenesis.

Purpose of the Study:

  • To investigate the role of FGFs in skin appendage induction.
  • To elucidate the signaling pathways involved in FGF-mediated feather bud development.

Main Methods:

  • Developing chicken feather buds were cultured in vitro.
  • FGF-1, FGF-2, or FGF-4 were applied to cultures via medium or Affigel blue beads.
  • Expression of intracellular signaling molecules (Grb, Ras, Raf, Erk) and Shh was analyzed.
  • Tyrosine kinase inhibitor (Genistein) was used to assess pathway involvement.

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Main Results:

  • FGFs induced feather bud formation in normally featherless skin regions.
  • FGFs promoted fusion and expansion of feather bud domains.
  • Newly induced feather buds expressed Sonic hedgehog (Shh).
  • FGF signaling pathway components (Grb, Ras, Raf, Erk) were enriched in feather bud domains.
  • Genistein inhibited FGF-induced feather bud formation.

Conclusions:

  • FGFs play a significant role in facilitating skin appendage domain formation.
  • Epithelial competence influences the response to FGFs.
  • FGF signaling, involving tyrosine kinases, is crucial for feather bud induction and development.