Effect of a herbomineral preparation D-400 in streptozotocin-induced diabetic rats

This study was undertaken to investigate the effect of D-400, a herbomineral formulation on blood sugar and other biochemical parameters in streptozotocin-induced diabetic rats. There was significant reduction in blood urea nitrogen, serum creatinine and serum uric acid levels in the D-400-treated group and considerable lowering of AUC in oral glucose tolerance test (OGTT). The D-400-treated group showed significant lowering of triglycerides and HDL cholesterol. There was a rise in hepatic glycogen level close to normal after D-400 treatment. In the pancreas of diabetic rats, D-400 therapy showed significant increase in islet number and beta cell count and appeared to bring about blood sugar homoeostasis by increasing insulin secretion and repair/regeneration of endocrine pancreas.