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Cosolvent solubilization and formulation of an aqueous injection of ketoprofen
A K Singhai1, S Jain, N K Jain
1Department of Pharmaceutical Sciences, University of Saugar, India.
Die Pharmazie
|October 1, 1996
Abstract:
Ketoprofen (1) an analgesic, antipyretic and anti-inflammatory agent, is practically insoluble in water. An increase in the aqueous solubility of 1 was attempted by various cosolvents. The solubility increased up to 8556 times (maximum) in case of ethanol while it was 33 times (minimum) in case of glycerol. Using selected cosolvents and hydrotropes, aqueous injections of 1 were formulated.