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Photochemical stability of norfloxacin in solutions, bulk form and tablets
O A al-Deeb1, E M Abdel-Moety, M A Abounassif
1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Bollettino Chimico Farmaceutico
|June 1, 1996
Abstract:
Accelerated photochemical degradation of norfloxacin in solutions, bulk forms, and tablets has been undertaken. The kinetic order of the drug photodegradation was determined by monitoring residual drug masses as a function of time matched with initial matched mass by adopting the HPLC-method of USP-23. A new dimeric photodegradate, formed from the active decarboxylated norfloxacin monomer, could be isolated and characterized.