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Current management of obesity

J S Cheah1

  • 1Department of Medicine, National University Hospital, Singapore.

Singapore Medical Journal
|June 1, 1996
PubMed
Summary

Obesity is a growing health concern. While antiobesity drugs offer short-term benefits, long-term solutions and new research into peptides and hormones like leptin are crucial for effective obesity treatment.

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Pharmacology

Background:

  • Obesity prevalence is increasing globally and in Singapore.
  • Obesity contributes significantly to morbidity and mortality.
  • Identifying underlying causes is essential before initiating obesity treatment.

Purpose of the Study:

  • To review current and experimental treatments for obesity.
  • To discuss the role of antiobesity drugs and surgical interventions.
  • To highlight recent advancements in obesity research.

Main Methods:

  • Review of existing literature on obesity treatments.
  • Discussion of pharmacological agents (serotonergic, adrenergic).
  • Exploration of peptide-based therapies and surgical options.

Main Results:

  • Short-term efficacy and safety of certain antiobesity drugs (e.g., fenfluramine) are established.
  • Long-term effectiveness of antiobesity drugs requires further investigation.
  • Experimental peptide therapies show weight reduction potential.
  • Surgery (e.g., gastric plication) can be life-saving in morbid obesity.

Conclusions:

  • Antiobesity drugs play a short-term role in comprehensive obesity management.
  • Ongoing research into peptides and novel targets like leptin and neuropeptide Y holds promise for future treatments.
  • Multifaceted approaches including diet, exercise, behavior modification, and potentially surgery are key to managing obesity.

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