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Functional imaging of the retina using the multifocal electroretinograph: a control study
S Parks1, D Keating, T H Williamson
1Tennent Institute of Ophthalmology, West Glasgow University NHS Trust.
The British Journal of Ophthalmology
|September 1, 1996
Summary
This study introduces a new retinal functional mapping technique, establishing normative values and assessing its reproducibility in healthy volunteers. Results show consistent implicit times but decreasing reproducibility with retinal eccentricity.
Area of Science:
- Ophthalmology
- Neuroscience
- Medical Imaging
Background:
- A novel technique for functional retinal mapping has been developed.
- Establishing normative data and assessing test reproducibility are crucial for clinical application.
Purpose of the Study:
- To obtain normative values for a new retinal functional mapping technique.
- To evaluate the reproducibility of this technique in healthy individuals.
Main Methods:
- Twenty healthy volunteers underwent testing with a 61-hexagon array stimulus over 14 minutes.
- Implicit times and amplitude measures were analyzed, with reproducibility assessed using Wilcoxon and Bland and Altman methods.
- Repeat measurements were conducted on 10 participants to quantify test-retest reliability.
Main Results:
- Implicit times for waveform components (b-wave: 35.52 ms, a-wave: 17.76 ms) showed no significant variation across the retina.
- Reproducibility demonstrated a decline with increasing eccentricity, with coefficients of repeatability ranging from 17.4% centrally to 30.3% peripherally.
Conclusions:
- The functional retinal mapping technique exhibits reproducibility comparable to conventional electrophysiology, despite variability with eccentricity.
- Established limits of variation will enable confidence interval assignment for individual retinal areas in future studies of diseased states.