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Fluoxetine augmentation of clozapine treatment in patients with schizophrenia
R W Buchanan1, B Kirkpatrick, N Bryant
1Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA.
Objective:
The authors examined the efficacy of fluoxetine augmentation of clozapine treatment response in schizophrenic outpatients who, despite adequate treatment with clozapine, continued to exhibit persistent positive or negative symptoms.
Method:
Thirty-three patients completed on 8-week, double-blind, parallel-groups comparison of adjunctive fluoxetine and placebo.
Results:
There were no significant differences in positive, negative, depressive, or obsessive-compulsive symptoms between patients given adjunctive fluoxetine or placebo.
Conclusions:
These results suggest that fluoxetine is not effective in augmenting clozapine treatment response.