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Related Experiment Videos

Dobutamine infusion modifies thermoregulation during general anesthesia

T Shitara1, Z Wajima, R Ogawa

  • 1Department of Anesthesiology, Nippon Medical School, Tokyo, Japan.

Anesthesia and Analgesia
|December 1, 1996
PubMed
Summary

Dobutamine infusion during anesthesia may increase hypothermia by enhancing body heat redistribution and skin heat loss. This suggests dobutamine use could lead to greater core temperature decreases in patients.

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Area of Science:

  • Anesthesiology
  • Physiology
  • Thermoregulation

Background:

  • Core body temperature decreases during anesthesia due to heat redistribution.
  • Dobutamine is an inotropic agent with potential effects on peripheral circulation.

Purpose of the Study:

  • To investigate if dobutamine infusion facilitates heat redistribution and exacerbates hypothermia during anesthesia.

Main Methods:

  • Volunteers received isoflurane anesthesia.
  • The experimental group received dobutamine infusion (4 µg·kg⁻¹·min⁻¹).
  • Core and peripheral temperatures, tissue temperature, and skin perfusion were measured.

Main Results:

  • Leg heat content decreased more in the control group than the dobutamine group.

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  • Core temperature decreased more in the dobutamine group compared to the control group.
  • Dobutamine facilitated heat transfer and increased cutaneous heat loss.

    • Conclusions:

    • Dobutamine infusion during anesthesia can induce further hypothermia.
    • This effect is likely due to enhanced heat redistribution and increased cutaneous heat loss.
    • Clinicians should consider the potential for increased hypothermia when using dobutamine during anesthesia.