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Endophthalmitis associated with microbial keratitis

I U Scott1, H W Flynn, W Feuer

  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL, USA.

Ophthalmology
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

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Endophthalmitis following microbial keratitis often occurs in patients with prior eye conditions, corticosteroid use, and immune dysfunction. Visual outcomes are frequently poor, highlighting the need for prompt treatment.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Microbial keratitis can lead to endophthalmitis, a serious intraocular infection.
  • Risk factors and outcomes for endophthalmitis associated with microbial keratitis require further investigation.

Purpose of the Study:

  • To identify risk factors, common organisms, and visual acuity outcomes in patients with endophthalmitis secondary to microbial keratitis.

Main Methods:

  • A retrospective review of patient records from January 1990 to March 1995 at Bascom Palmer Eye Institute.
  • Inclusion criteria: patients with positive corneal and intraocular cultures.

Main Results:

  • Most patients (92.9%) had documented keratitis preceding endophthalmitis.

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  • Frequent risk factors included corticosteroid use (92.9%), immune dysfunction (35.7%), ocular surgery history (57.1%), and corneal abnormalities (perforation 28.6%, wound abnormalities 50.0%).
  • Commonly isolated organisms were Gram-negative bacteria, Staphylococcus aureus, streptococci, and fungi. Visual acuity outcomes were often poor (42.9% achieved 20/200 or better), with some cases requiring eye removal (21.4%).

    • Conclusions:

    • Endophthalmitis associated with microbial keratitis is linked to corticosteroid use, immune dysfunction, and ocular structural abnormalities.
    • The causative organisms differed from those typically seen in postoperative endophthalmitis.
    • Visual outcomes are generally poor, emphasizing the severity of this condition.