Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Binding of human complement component C4b-binding protein (C4BP) to Streptococcus pyogenes involves the C4b-binding

P Accardo1, P Sánchez-Corral, O Criado

  • 1Department of Immunology, Center for Biological Research, CSIC, Madrid, Spain.

Journal of Immunology (Baltimore, Md. : 1950)
|December 1, 1996
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cadmium-binding peptide in whole cells of Acetabularia calyculus.

Bulletin of environmental contamination and toxicology·2003
Same author

Centrality dependence of charged-hadron transverse-momentum spectra in d+Au collisions at sqrt[s(NN)]=200 GeV.

Physical review letters·2003
Same author

Significance of the fragmentation region in ultrarelativistic heavy-ion collisions.

Physical review letters·2003
Same author

Severe hemolytic anemia and skin reaction in a patient treated with imatinib.

Annals of oncology : official journal of the European Society for Medical Oncology·2003
Same author

[Effect of growth hormone and calcitriol on the growth plate in uremic rats].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2003
Same author

Is azithromycin the first-choice macrolide for treatment of community-acquired pneumonia?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2003

Streptococcus pyogenes evades the immune system by mimicking human complement protein C4b. This molecular mimicry allows bacteria to bind human C4b-binding protein (hC4BP), hindering pathogen elimination.

Area of Science:

  • Immunology
  • Microbiology
  • Molecular Biology

Background:

  • The complement system is crucial for eliminating pathogens via C3b and C4b protein deposition.
  • Pathogens like Streptococcus pyogenes possess mechanisms to evade host complement defenses.

Purpose of the Study:

  • To elucidate the molecular mechanism by which Streptococcus pyogenes interacts with human C4b-binding protein (hC4BP).
  • To understand how this interaction impacts complement deposition on the bacterial surface.

Main Methods:

  • Investigated the binding interaction between streptococcal surface molecules and hC4BP.
  • Characterized the specific binding site on hC4BP involved in the interaction.

Main Results:

  • Streptococcal surface molecules bind to hC4BP at a site identical to the C4b binding site.

Related Experiment Videos

  • The interaction involves multiple binding surfaces within the short consensus repeats 1-3 of hC4BP's alpha-chain.

    • Conclusions:

    • Streptococcus pyogenes employs molecular mimicry, presenting surface structures that resemble human C4b epitopes.
    • This mimicry facilitates binding to hC4BP, potentially downregulating complement-mediated bacterial clearance.