Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis C and bile duct loss

R D Goldin1, N K Patel, H C Thomas

  • 1Department of Histopathology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London.

Journal of Clinical Pathology
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Initial experience using middle meningeal artery embolisation for patients with recurrent and high-recurrence-risk chronic subdural haematoma.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2024
Same author

Evaluation of painful total knee arthroplasty: an approach based on common etiologies for total knee arthroplasty revision.

Musculoskeletal surgery·2023
Same author

Ultrasound simulation training to meet the 2021 Royal College of Radiologists' curriculum for radiology trainees: South East London experience.

Clinical radiology·2023
Same author

Advanced glycation end-product accumulation differs by location and sex in aged osteoarthritic human menisci.

Osteoarthritis and cartilage·2022
Same author

Examination of the periaqueductal gray as a site for controlling arterial pressure in the conscious spontaneously hypertensive rat.

Autonomic neuroscience : basic & clinical·2022
Same author

Antegrade femoral nailing in the lateral decubitus position: a case series, technical tips and review of literature.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2022

Chronic hepatitis C is linked to bile duct loss, particularly in advanced liver disease stages. However, the observed bile duct loss in this study did not reach statistically significant levels, suggesting other factors may contribute.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Virology

Background:

  • Chronic hepatitis C (HCV) is a significant cause of liver disease worldwide.
  • Bile duct damage is a known complication in various chronic liver conditions.
  • The specific association between HCV and bile duct loss requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between chronic hepatitis C infection and bile duct loss in liver biopsy specimens.
  • To quantify bile duct loss in patients with chronic hepatitis C compared to those with chronic hepatitis B and healthy controls.

Main Methods:

  • Analysis of liver biopsy sections from 171 patients with chronic hepatitis C.
  • Comparison with biopsy specimens from 98 patients with chronic hepatitis B and 23/25 control subjects.

Related Experiment Videos

  • Quantification of bile duct loss using the bile duct to portal tract ratio.

    • Main Results:

    • The bile duct to portal tract ratio was lower in the chronic hepatitis C group (0.89) compared to hepatitis B (0.93) and control groups (0.96, 0.90).
    • Greater bile duct loss was observed in cirrhotic patients within the hepatitis C cohort.
    • No case of chronic hepatitis C showed a ratio below 0.60, indicating loss did not exceed 50%.

    Conclusions:

    • Chronic hepatitis C is associated with bile duct loss, with severity correlating with disease stage.
    • While a link exists, the observed bile duct loss in this study did not reach conventionally significant levels (>50%).
    • Hepatitis C may contribute to bile duct loss, especially when other risk factors are present, particularly in liver transplant recipients.