Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Naevocyte triggering by recombinant human growth hormone

G E Piérard1, C Piérard-Franchimont, A Nikkels

  • 1Department of Dermatopathology and Pediatrics, University of Liège, Belgium.

The Journal of Pathology
|September 1, 1996
PubMed
Summary

Recombinant human growth hormone (hGH) treatment can activate melanocytes, leading to atypical melanocytic naevi in children. While not malignant, these hGH-triggered lesions require careful long-term evaluation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recommendations for skin cancer consultation and surgery during COVID-19 pandemic.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Practical recommendations for systemic treatment in psoriasis in case of coexisting inflammatory, neurologic, infectious or malignant disorders (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 2).

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Practical recommendations for systemic treatment in psoriasis according to age, pregnancy, metabolic syndrome, mental health, psoriasis subtype and treatment history (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 1).

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Should we provide anti-human papillomavirus vaccination for patients with genital hidradenitis suppurativa?

The British journal of dermatology·2018
Same author

Vitamin D supplementation in cutaneous malignant melanoma outcome (ViDMe): a randomized controlled trial.

BMC cancer·2017
Same author

[Vitamin D anti-cancer activities: observations, doubts and certainties].

Revue medicale de Liege·2016

Area of Science:

  • Endocrinology
  • Dermatology
  • Oncology

Background:

  • Growth hormone (GH) and insulin-like growth factor I (IGF-I) influence human melanocytes.
  • Clinical observations link recombinant human growth hormone (hGH) therapy to increased melanocytic naevi growth in children.

Purpose of the Study:

  • To investigate the cellular and molecular changes in melanocytic naevi triggered by hGH therapy.
  • To assess the atypicality of naevocytes in hGH-treated children compared to controls.

Main Methods:

  • Analysis of 56 hGH-triggered naevi and 9 lesions from patients with hypopituitarism/Turner's syndrome.
  • Comparison with 40 naevi from age-matched healthy children.
  • Utilized image analysis, AgNOR counts, immunohistochemistry (HMB-45, NKI-C3, Ki-67, anti-bcl-2-oncoprotein), and DNA flow cytometry.

Related Experiment Videos

Main Results:

  • hGH treatment correlated with anisokaryosis and increased AgNOR and Ki-67 counts in naevocytes.
  • Abnormal HMB-45 immunolabelling patterns were observed in hGH-treated naevocytes.
  • These cellular changes indicated naevocyte activation, not malignant transformation.

Conclusions:

  • hGH-triggered melanocytomas exhibit atypical features and should be classified as atypical melanocytic naevi.
  • The long-term evolution and malignant transformation potential of these lesions require further investigation.