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Severe coagulation abnormalities in Reye syndrome

C Pegelow, R Goldberg, S Turkel

The Journal of Pediatrics

|September 1, 1977

Summary

This summary is machine-generated.

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Reye syndrome can cause severe bleeding complications due to coagulation defects. Some children require transfusions before procedures, indicating consumption coagulopathies alongside decreased factor production.

Area of Science:

Pediatric Medicine
Hematology
Hepatology

Background:

Reye syndrome is a rare but serious condition affecting children, often following viral illnesses.
Coagulation abnormalities are a known complication, but their severity and mechanisms require further elucidation.

Observation:

Coagulation studies were conducted on 13 children diagnosed with Reye syndrome.
Four children presented with severe coagulopathies necessitating transfusion of coagulation factors and platelets before liver biopsy.

Findings:

Two children exhibited disseminated intravascular coagulation (DIC).
One child showed abnormalities consistent with DIC, while another presented with typical acute hepatic failure-associated coagulopathies.
While decreased coagulation factor production is common, these cases highlight the role of consumption coagulopathies in Reye syndrome.

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Implications:

Coagulation defects in Reye syndrome can be severe, posing significant bleeding risks.
Prompt recognition and management of coagulopathies are crucial for safe diagnosis and treatment of Reye syndrome.
These findings underscore the need for comprehensive coagulation assessment in affected children.