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Related Experiment Videos

[Vision in Alzheimer's disease]

M Ceccaldi1

  • 1Service de Neurologie et de Neuropsychologie, CHU La Timone, Marseille.

Revue Neurologique
|June 1, 1996
PubMed
Summary

Visual disturbances are early signs of Alzheimer disease (AD). Research shows the occipito-parietal cortex, crucial for visuo-spatial functions, is selectively impacted in AD patients.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neuropathology

Context:

  • Alzheimer disease (AD) often presents with initial visual function disturbances.
  • Balint's syndrome, linked to AD, shows an occipito-parietal predominance of neurofibrillary tangles (NFT) and neuritic plaques (NP).

Purpose:

  • To investigate the selective involvement of visual processing areas in Alzheimer disease.
  • To correlate neuropathological findings with visual deficits in dementia of Alzheimer type (DAT).

Summary:

  • Patients with DAT exhibit deficits in stereo-acuity, motion sensitivity, contrast sensitivity, and backward masking.
  • Electrophysiological studies reveal abnormalities in flash visual evoked potentials but not pattern visual evoked potentials.
  • Neuroimaging indicates reduced glucose metabolism in the visual association and parietal cortex.
  • Pathological studies confirm the involvement of the associative visual cortex with relative preservation of the primary visual cortex.

Impact:

  • Findings suggest the dorsal visual system (occipito-parietal cortex), responsible for visuo-spatial functions, is a primary target in Alzheimer disease.
  • This highlights the importance of visual assessments in early AD diagnosis and understanding disease progression.

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