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Well-differentiated thyroid carcinoma

K Segal1, E Raveh, E Lubin

  • 1Department of Otolaryngology, Beilinson Medical Center, Petah Tiqva, Israel.

American Journal of Otolaryngology
|November 1, 1996
PubMed
Summary
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This study analyzed 728 well-differentiated thyroid carcinoma patients, finding 17.2% developed metastases, often within 10 years. Aggressive treatment is recommended for thyroid cancer management.

Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Well-differentiated thyroid carcinoma (WDTC) is a common endocrine malignancy.
  • Long-term outcomes and prognostic factors require continuous evaluation.
  • Understanding metastasis patterns is crucial for effective patient management.

Purpose of the Study:

  • To report the clinical experience with 728 patients treated for WDTC.
  • To evaluate prognostic implications of clinical and pathological findings.
  • To identify risk factors influencing patient prognosis.

Main Methods:

  • Retrospective analysis of 728 WDTC patients treated between 1954-1994.
  • Evaluation of prognostic factors including age, sex, histology, tumor size, and spread.

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  • Long-term follow-up ranging from 1 to 31 years.

    • Main Results:

    • 17.2% of patients developed locoregional and/or distant metastases.
    • 87 metastases occurred within the first 10 years post-therapy.
    • Thyroid cancer contributed to mortality in 52 patients (32 papillary, 20 follicular).

    Conclusions:

    • Experience suggests an aggressive treatment approach for WDTC.
    • Early detection and management of metastases are critical.
    • Prognostic factor evaluation informs treatment strategy.