Diphencyprone in the management of refractory palmoplantar and periungual warts: an open study

Induction of delayed-type hypersensitivity has recently been introduced for resistant viral warts. The method is not painful and less destructive than most other modalities.

We assessed the efficacy of topical diphencyprone (diphenylcyclopropenone) treatment for recalcitrant warts.

From September 1988 to June 1995, 134 patients with periungual and/or palmoplantar warts were entered into the study. Eight weekly applications were delivered.

The scheduled treatment course and follow-up were completed by 111 patients. There were 49 complete and 18 partial remissions. The rate of positive responders (60%) compares with the results published by other authors.

Diphencyprone is an effective treatment for resistant warts, especially in palmoplantar and periungual locations.