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Updated: Jan 11, 2026

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5-hydroxytryptamine release into human jejunum by cholera toxin

C P Bearcroft¹, D Perrett, M J Farthing

¹Digestive Diseases Research Centre, St Bartholomew's, London.

|October 1, 1996

Summary

Cholera toxin triggers intestinal fluid secretion in humans. This study found that cholera toxin also releases 5-hydroxytryptamine (serotonin) into the jejunum, suggesting a role in cholera's secretory effects.

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Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

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Area of Science:

Gastroenterology
Molecular Biology
Pharmacology

Background:

Cholera toxin activates adenylate cyclase, causing intestinal secretion.
Animal studies suggest 5-hydroxytryptamine (serotonin) release contributes to cholera toxin-induced secretion.

Purpose of the Study:

To investigate if cholera toxin induces 5-hydroxytryptamine release in the human jejunum.

Main Methods:

A double-blind, randomized study exposed human jejunal segments to cholera toxin.
Measured 5-hydroxytryptamine in jejunal effluent and 5-hydroxyindoleacetic acid in urine using HPLC.

Main Results:

Cholera toxin induced significant fluid secretion in the jejunum.
5-hydroxytryptamine was detected in the jejunal lumen after cholera toxin exposure.
Urinary 5-hydroxyindoleacetic acid levels did not change significantly.

Conclusions:

Cholera toxin stimulates 5-hydroxytryptamine release into the human jejunal lumen.
5-hydroxytryptamine may mediate cholera toxin-induced intestinal secretion in humans.

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Last Updated: Jan 11, 2026

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants