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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jul 21, 2026

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E
09:48

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Published on: September 26, 2019

Leucocyte adhesion deficiency presenting as a chronic ileocolitis

I D D'Agata1, K Paradis, Z Chad

  • 1Division of Paediatric, Gastroenterology, Hôpital Ste-Justine, Montreal, Canada.

Gut
|October 1, 1996
PubMed
Summary

CD11/CD18 leucocyte glycoprotein deficiency, a rare congenital disorder, causes severe infections due to abnormal leukocyte function. Bone marrow transplant resolved ileocolitis, highlighting neutrophil dysfunction

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Area of Science:

  • Immunology
  • Gastroenterology
  • Hematology

Background:

  • CD11/CD18 leucocyte glycoprotein deficiency is a rare congenital disorder affecting leukocyte adhesion and migration.
  • This deficiency leads to susceptibility to life-threatening infections.

Observation:

  • This report details the first case of CD11/CD18 deficiency presenting as chronic ileocolitis.
  • Affected individuals exhibit abnormal leukocyte migration and adherence.

Findings:

  • Bone marrow transplantation successfully resolved gastrointestinal symptoms in the reported case.
  • Neutrophil dysfunction plays a significant role in the pathogenesis of gut lesions associated with this deficiency.

Implications:

  • Specific blockade of CD11/CD18 integrins may not be sufficient to manage chronic inflammation in immune-mediated bowel disorders.
  • Leukocyte function abnormalities should be considered in the differential diagnosis of pediatric Crohn's disease.