Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacterial adhesion on polyurethane surfaces conditioned with thrombus components

J N Baumgartner1, S L Cooper

  • 1Department of Chemical Engineering, University of Delaware, Newark 19716, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emergent Vibronic Excitations in the Magnetodielectric Regime of Ce_{2}O_{3}.

Physical review letters·2019
Same author

Adjuvant irradiation to prevent keloidal fibroproliferative growth should be standard of care.

The British journal of dermatology·2017
Same author

Assessment of the construct validity of the Australian Health Star Rating: a nutrient profiling diagnostic accuracy study.

European journal of clinical nutrition·2017
Same author

An Absorbed-Dose/Dose-Rate Dependence for the Alanine-EPR Dosimetry System and Its Implications in High-Dose Ionizing Radiation Metrology.

Journal of research of the National Institute of Standards and Technology·2016
Same author

Inelastic light scattering measurements of a pressure-induced quantum liquid in KCuF3.

Physical review letters·2012
Same author

Social integration in global mental health: what is it and how can it be measured?

Epidemiology and psychiatric sciences·2012
Same journal

Machine Learning Prediction of Pediatric In-Hospital Survival Before Extracorporeal Membrane Oxygenation Cannulation.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Erratum: Safety and Efficacy of Stored Wet-Preprimed Extracorporeal Membrane Oxygenation Circuits: A Scoping Review.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Case Series of Extracorporeal Cardiopulmonary Resuscitation for Refractory Cardiopulmonary Arrest After Cardiac Surgery.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Association Between Veno-Venous Extracorporeal Membrane Oxygenation and Right Ventricular Dysfunction in Acute Respiratory Distress Syndrome Patients: A Multicenter Retrospective Propensity-Matched Study.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Prolonged Mechanical Circulatory Support of Neonatal Biventricular Failure via Single Ventricle Conversion With Ventricular Assist Device.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Redefining Limits: Extracorporeal Cardiopulmonary Resuscitation in Adult Thrombotic Thrombocytopenic Purpura.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
See all related articles

Phosphonated polyurethane surfaces significantly reduced Staphylococcus aureus adhesion compared to other tested materials. This finding is crucial for developing safer cardiovascular devices by minimizing both thrombosis and infection risks.

Area of Science:

  • Biomaterials Science
  • Infectious Diseases
  • Cardiovascular Engineering

Background:

  • Cardiovascular devices like grafts and catheters are prone to thrombosis and infection.
  • Blood contact with biomaterials triggers protein deposition, coagulation, and platelet activation, leading to thrombus formation.
  • Bacterial infections are common with indwelling devices, potentially linked to thrombosis.

Purpose of the Study:

  • To investigate Staphylococcus aureus adhesion to modified polyurethane surfaces simulating clot formation.
  • To evaluate the impact of pre-adsorbed proteins and platelets on bacterial adhesion.
  • To identify biomaterial surface properties that reduce bacterial adhesion and associated risks.

Main Methods:

  • Examined Staphylococcus aureus adhesion to sulfonated, aminated, and phosphonated polyurethane surfaces.

Related Experiment Videos

  • Pre-adsorbed surfaces with solutions of increasing complexity (albumin, fibrinogen, plasma, thrombin, platelets).
  • Utilized video microscopy with automated image analysis and scanning electron microscopy.

    • Main Results:

    • Bacterial adhesion was lowest on phosphonated polyurethane surfaces.
    • Fibrin or isolated platelets significantly increased bacterial adhesion compared to albumin.
    • Simulated clot components enhanced bacterial adherence to tested surfaces.

    Conclusions:

    • Phosphonated polyurethane surfaces show potential for reducing bacterial adhesion in cardiovascular devices.
    • Minimizing thrombus formation on biomaterials may decrease infection risk.
    • Surface modification of biomaterials is key to improving device safety and biocompatibility.