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Related Experiment Videos

Heart rate variability in isolated rabbit hearts

B Frey1, G Heger, C Mayer

  • 1Department of Internal Medicine II, University of Vienna, Austria.

Pacing and Clinical Electrophysiology : PACE
|November 1, 1996
PubMed
Summary

Isolated, denervated rabbit hearts exhibit random heart rate variability (HRV). This HRV, characterized by broadband fluctuations, was present in both Langendorff and working heart modes, unaffected by filling pressures.

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Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Research

Background:

  • Heart rate variability (HRV) is a well-established indicator of cardiac autonomic function in intact hearts.
  • The presence of HRV in denervated hearts post-transplantation prompted investigation into HRV in isolated, denervated cardiac preparations.

Purpose of the Study:

  • To investigate the characteristics of heart rate variability (HRV) in isolated, denervated rabbit hearts.
  • To determine if different perfusion modes (Langendorff vs. working heart) influence HRV in these preparations.

Main Methods:

  • Seven adult ELCO rabbit hearts were isolated and perfused using both Langendorff and working heart modes for 20 minutes each.
  • Heart rate variability (HRV) was analyzed in the frequency domain.
  • A simulated ECG was used for system error estimation.

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Main Results:

  • Isolated, denervated hearts displayed HRV as random, broadband fluctuations, distinct from intact hearts.
  • No significant differences in HRV measures were found between Langendorff and working heart modes.
  • Left atrial and ventricular filling in the working heart mode did not alter HRV.

Conclusions:

  • Heart rate variability (HRV) is present in isolated, denervated rabbit hearts.
  • Cardiac filling pressures in the working heart mode do not influence the sinus nodal discharge rate in denervated hearts.