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Antiandrogen. IV. C-17 spiro 2-oxasteroids

N Koizumi¹, S Takegawa, M Mieda

¹Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.

Chemical & Pharmaceutical Bulletin

|November 1, 1996

Abstract:

The preparation of 6- and/or 7-substituted 3-oxo-2-oxasteroids having a spirotetrahydrofuran ring at the 17-position is described. These compounds showed high antiandrogenic potency in the castrated male rat.

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