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Ischemic preconditioning in human and rat ventricle

J C Cleveland¹, M M Wollmering, D R Meldrum

¹Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA.

The American Journal of Physiology

|November 11, 1996

Summary

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Ischemic preconditioning protects heart muscle from injury. This study shows that both rat and human ventricles can be functionally protected against hypoxia-reoxygenation through simulated ischemia and receptor signaling.

Area of Science:

Cardiology
Physiology
Molecular Biology

Background:

Ischemic preconditioning activates receptor systems like alpha 1-adrenoceptors and adenosine receptors.
Its clinical utility and protective effects on the human ventricle against hypoxia-reoxygenation remain unclear.

Purpose of the Study:

To investigate if human ventricular myocardium can be functionally protected against hypoxia-reoxygenation.
To determine the role of simulated ischemia, alpha 1-adrenergic, and adenosine receptor stimulation in this protection.

Main Methods:

Isolated rat ventricles and human ventricular trabeculae were subjected to hypoxia-reoxygenation.
Preconditioning was induced via simulated ischemia, alpha 1-adrenoceptor stimulation (phenylephrine), or adenosine receptor stimulation (adenosine).

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Recovery of developed tension was measured post-insult.

Main Results:

In rats, preconditioning significantly improved tension recovery (56-58%) compared to controls (25%).
In human trabeculae, preconditioning also significantly augmented tension recovery (60-65%) versus controls (29%).
Both alpha 1-adrenergic and adenosine receptor stimulation conferred protection in both species.

Conclusions:

Functional cardioadaptation (preconditioning) against hypoxia-reoxygenation injury exists in both rat and human myocardium.
Alpha 1-adrenergic and adenosine receptor signaling pathways are crucial in mediating this protective effect.