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Epstein-Barr virus and human T-cell lymphomas

C J Meijer1, N M Jiwa, D F Dukers

  • 1Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.

Seminars in Cancer Biology
|August 1, 1996
PubMed
Summary

Epstein-Barr virus (EBV) is linked to T-cell lymphomas (T-NHL) in immunocompetent individuals, particularly nasal T-NHL. EBV

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Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Epstein-Barr virus (EBV) is traditionally linked to B-cell lymphoproliferations.
  • Recent molecular studies reveal EBV's association with T-cell non-Hodgkin lymphomas (T-NHL).

Purpose of the Study:

  • To discuss the role of Epstein-Barr virus in the pathogenesis of T-cell lymphomas.
  • To highlight the site-specific distribution and prognostic implications of EBV in T-NHL.

Main Methods:

  • Molecular biological techniques were employed to detect EBV.
  • Analysis of EBV association in various T-NHL subtypes and anatomical sites.
  • Evaluation of LMP1 protein expression and its prognostic significance.

Main Results:

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  • EBV is associated with T-NHL in non-immunocompromised patients.
  • EBV-associated T-NHL shows site predilection: 100% in nasal, 20% in lung/gastrointestinal, rare in cutaneous T-cell lymphomas.
  • LMP1 protein expression correlates with a poor prognosis in EBV-associated T-NHL.

Conclusions:

  • Epstein-Barr virus plays a role in the pathogenesis of specific T-cell lymphomas.
  • Site-specific distribution and LMP1 expression are key factors in EBV-associated T-NHL prognosis.