Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thymic and extrathymic T cell development

G Leclercq1, J Plum

  • 1Department of Clinical Chemistry, Microbiology and Immunology, University of Ghent, Belgium.

Leukemia
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case Report: Atypical acute compartment syndrome of the forearm in a child following minor trauma with consecutive osteomyelitis.

Frontiers in surgery·2024
Same author

[74-year-old man with a complex acromio-clavicular disjunction].

Revue medicale de Bruxelles·2018
Same author

[Interest of non invasive navigation in total knee arthroplasty].

Revue medicale de Bruxelles·2015
Same author

In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection.

Leukemia·2013
Same author

Identification of polyproline II regions derived from the proline-rich nuclear receptor coactivators PNRC and PNRC2: new insights for ERα coactivator interactions.

Chirality·2013
Same author

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway.

Leukemia·2011
Same journal

Single-cell architecture of purinergic signaling in human cord blood hematopoietic stem and progenitor cells.

Leukemia·2026
Same journal

Feasibility and safety of rapid glofitamab ramp-up.

Leukemia·2026
Same journal

Single-cell DNA methylation analysis uncovers epigenetic pathways in the transformation of MDS to AML.

Leukemia·2026
Same journal

PD-L2 is associated with lineage-related transcriptional programs distinct from PD-L1 in primary mediastinal large B-cell lymphoma.

Leukemia·2026
Same journal

Lineage-restricted dependency on an oncofetal SNHG29-IGF2BP1 RNA axis in acute megakaryoblastic leukemia.

Leukemia·2026
Same journal

Selective targeting of RSK signaling with PMD-026 suppresses FLT3-activated acute myeloid leukemia while sparing normal hematopoiesis.

Leukemia·2026
See all related articles

Most T cells require the thymus for development, but a significant population of thymus-independent T cells resides in the gut. This review explores their distinct characteristics and development.

Area of Science:

  • Immunology
  • Cell Biology
  • Developmental Biology

Background:

  • T cells are crucial for adaptive immunity, with most requiring thymic education.
  • A distinct population of T cells bypasses thymic selection, particularly in the gut epithelium.

Purpose of the Study:

  • To review the phenotypic and functional characteristics of T cell development.
  • To summarize cytokine requirements and selection processes in T cell differentiation.
  • To highlight differences between thymic-dependent and thymic-independent T cells.

Main Methods:

  • Review of existing literature on T cell development.
  • Analysis of phenotypic and functional data.
  • Comparison of thymic-dependent and independent T cell populations.

Related Experiment Videos

Main Results:

  • Thymic-independent T cells are abundant in the gut epithelium, unlike in peripheral lymphoid organs.
  • Distinct selection processes, CD4-CD8 expression, and CD3 complex composition differentiate T cell subsets.

Conclusions:

  • T cell development is not solely thymus-dependent, with significant thymus-independent populations existing.
  • Understanding these distinct T cell populations is key to comprehending immune responses, especially in mucosal tissues.