Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary herpes simplex in burns patients

R J Byers1, P S Hasleton, A Quigley

  • 1Dept of Pathological Sciences, University of Manchester, Manchester Royal Infirmary, UK.

The European Respiratory Journal
|November 1, 1996
PubMed
Summary

Herpes simplex virus (HSV) is common in the lungs of burn patients, strongly linked to adult respiratory distress syndrome (ARDS). Early detection of pulmonary HSV in burn victims may improve outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microglia in human models of development and disease: are we prioritising model 'success' over biological truth?

Neuroscience·2026
Same author

Bioengineered polymeric mesh with imaging contrast for enhanced urogynaecological applications.

Biomaterials advances·2025
Same author

Obstetrical Events Support Team (OEST): Preventing harm, reducing costs from neonatal brain injury.

Irish medical journal·2025
Same author

The risk of cognitive decline and dementia in older adults diagnosed with COVID-19: A systematic review and meta-analysis.

Ageing research reviews·2024
Same author

Could it be monkeypox? Use of an AI-based epidemic early warning system to monitor rash and fever illness.

Public health·2023
Same author

Horses are susceptible to natural, but resistant to experimental, infection with the liver fluke, Fasciola hepatica.

Veterinary parasitology·2020

Area of Science:

  • Medical Microbiology
  • Pulmonary Medicine
  • Burn Injury Research

Background:

  • Burn patients are susceptible to secondary infections.
  • Pulmonary complications significantly impact mortality in burn survivors.
  • The role of herpes simplex virus (HSV) in burn-related lung injury is not well understood.

Purpose of the Study:

  • To determine the incidence of pulmonary herpes simplex virus (HSV) in burn patients.
  • To investigate the association between HSV lung infection and adult respiratory distress syndrome (ARDS) or pneumonia.
  • To compare diagnostic methods for detecting HSV in lung tissue.

Main Methods:

  • Histopathological analysis of lung tissue using Haematoxylin and eosin (H&E) and immunohistochemical (IHC) staining.
  • Polymerase chain reaction (PCR) for HSV deoxyribonucleic acid (DNA) on a subset of samples.

Related Experiment Videos

  • Comparison of HSV detection rates between burn patients (n=54) and controls (n=9).

    • Main Results:

    • 50% of burn patients showed HSV positivity via IHC, compared to 0% in controls.
    • HSV infection was significantly associated with ARDS (p=0.007), with a relative risk of 2.21.
    • No significant association was found between HSV and pneumonia (p=0.577).
    • IHC was more sensitive than H&E for detecting HSV.
    • PCR results were potentially limited by postmortem tissue necrosis.

    Conclusions:

    • Pulmonary herpes simplex virus infection is highly prevalent in burn patients.
    • Pulmonary HSV is strongly associated with ARDS, suggesting a potential causal link.
    • Early diagnosis and treatment of pulmonary HSV in burn patients may reduce mortality and lung complications.