Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulsatile augmentation device for extracorporeal circulation

D B Doty1, N D Wang, B Y Chiang

  • 1Department of Surgery, LDS Hospital, Salt Lake City, Utah, USA.

Artificial Organs
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical aspects of endocarditis.

Heart, lung & circulation·2005
Same author

Serum lysophosphatidic acid concentrations measured by dot immunogold filtration assay in patients with acute myocardial infarction.

Scandinavian journal of clinical and laboratory investigation·2004
Same author

Cardiac valve replacement with mitral homograft.

Seminars in thoracic and cardiovascular surgery·2002
Same author

Impact of high transvalvular to subvalvular velocity ratio early after aortic valve replacement with Freestyle stentless aortic bioprosthesis.

Seminars in thoracic and cardiovascular surgery·2002
Same author

Anomalous origin of the left circumflex coronary artery associated with bicuspid aortic valve.

The Journal of thoracic and cardiovascular surgery·2001
Same author

Extra-anatomic aortic bypass for thoracic aortic obstruction.

The Journal of thoracic and cardiovascular surgery·2001
Same journal

Large-Eddy Simulation of the FDA Benchmark Blood Pump: Validation Against Experiments and Implications for Turbulent Flow Mechanisms.

Artificial organs·2026
Same journal

The Warm Revolution: A Meta-Analysis of DCD Versus DBD Liver Transplant Outcomes in the Normothermic Machine Perfusion Era.

Artificial organs·2026
Same journal

Toward Optimal Remote Monitoring in LVAD Recipients: Remaining Challenges Beyond Feasibility.

Artificial organs·2026
Same journal

Advancing Organ Preservation and Perfusion: Introducing the International Society of Organ Preservation and Perfusion Therapy (ISOPPT).

Artificial organs·2026
Same journal

Short Inter-Treatment Interval Treatment With Artificial Liver Support System Reduces 90-Day Transplant-Free Mortality in Patients With Hepatitis B Virus-Related Acute-On-Chronic Liver Failure: A Retrospective Observational Study.

Artificial organs·2026
Same journal

Extracorporeal Albumin Dialysis (OPAL) as Novel Therapeutic Bridging Option in Posthepatectomy Liver Failure.

Artificial organs·2026
See all related articles

A novel pulsatile augmentation device was developed for extracorporeal bypass circuits. This valveless, pneumatically driven device demonstrated effective blood compatibility and pulse augmentation in preliminary testing.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Medical Device Design

Background:

  • Standard extracorporeal bypass circuits often lack pulsatile flow, potentially impacting organ perfusion and function.
  • Restoring pulsatility during cardiopulmonary bypass or circulatory assist may offer significant clinical benefits.
  • Existing devices for pulsatile flow augmentation are limited in application or complexity.

Purpose of the Study:

  • To design, construct, and evaluate a novel device for delivering pulsatile pressure/flow to extracorporeal bypass circuits.
  • To assess the blood compatibility and hemodynamic performance of the pulsatile augmentation device.
  • To investigate the feasibility of integrating this device into standard cardiopulmonary bypass and right heart assist configurations.

Main Methods:

Related Experiment Videos

  • A pneumatically driven, valveless pulsatile augmentation device was fabricated using polyurethane via vacuum forming and high-frequency welding.
  • The device was driven by a modified Arrow-Kontron intra-aortic balloon pump or the Utah artificial heart driver.
  • In vitro testing utilized fresh bovine blood to evaluate blood compatibility and hemodynamic function. In vivo testing was performed in extracorporeal right and left heart bypass circuits for 4 hours.

Main Results:

  • In vitro studies confirmed acceptable blood compatibility and satisfactory hemodynamic function of the device.
  • In vivo testing demonstrated effective pulse augmentation in both pulmonary (right heart) and systemic (left heart) bypass circuits.
  • The device successfully provided pulsatile flow augmentation throughout the 4-hour experimental period.

Conclusions:

  • The developed pulsatile augmentation device is a promising technology for restoring pulsatility in extracorporeal circuits.
  • Its simple, valveless design and demonstrated efficacy suggest potential for improving outcomes in cardiopulmonary bypass and right heart circulatory assist.
  • Further research and clinical evaluation are warranted to explore its full therapeutic potential.