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Adhesion molecules in acute myeloid leukemia

E Paietta1

  • 1Montefiore and Albert Einstein Cancer Center, New York, NY 10467, USA.

Leukemia Research
|September 1, 1996
PubMed
Summary

Adhesion molecules regulate normal blood cell development by controlling cell interactions within the bone marrow. Alterations in these molecules impact cell attachment and behavior in both normal and leukemic hematopoiesis.

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Area of Science:

  • Hematology
  • Cell Biology
  • Immunology

Background:

  • Adhesion molecules are abundant on early bone marrow progenitor cells.
  • Their expression varies with cell differentiation stages.
  • Precursor cell interactions with the bone marrow microenvironment are crucial for cell retention or release.

Purpose of the Study:

  • To discuss the role of adhesion molecules in normal hematopoiesis.
  • To explore their involvement in acute myeloid leukemia (AML).
  • To address the diagnostic and physiological significance of leukocyte adhesion molecules.

Main Methods:

  • Review of existing literature on adhesion molecules in hematopoiesis and AML.
  • Analysis of the expression patterns and functions of adhesion molecules.
  • Discussion of the impact of altered adhesion molecule expression on cell behavior.

Main Results:

  • Adhesion molecules are critical for regulating hematopoietic cell migration and localization.
  • Changes in adhesion molecule expression affect cell attachment in normal development and disease.
  • Several adhesion molecules and their soluble forms are found in AML.

Conclusions:

  • Adhesion molecules are key regulators of hematopoietic cell behavior, influencing normal development and disease processes like AML.
  • Their altered expression can lead to abnormal cell attachment and migration.
  • Leukocyte adhesion molecules possess significant diagnostic and physiological relevance.

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