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Ca2+ signaling and intracellular Ca2+ binding proteins

I Niki1, H Yokokura, T Sudo

  • 1Department of Pharmacology, Nagoya University School of Medicine.

Journal of Biochemistry
|October 1, 1996
PubMed
Summary

Intracellular calcium-binding proteins are crucial for cell signaling, mediating diverse cellular responses. This review details their biochemical properties and roles in calcium (Ca2+) signal transduction.

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Cytosolic calcium (Ca2+) concentration changes trigger a wide array of cellular responses.
  • Intracellular Ca2+-binding proteins are central to transducing Ca2+ signals through enzymatic reactions or protein interactions.
  • These proteins include EF hand proteins (e.g., calmodulin, S100), Ca2+/phospholipid-binding proteins (annexins, C2 proteins), and Ca2+ storage proteins.

Purpose of the Study:

  • To review the biochemical properties of intracellular Ca2+-binding proteins.
  • To describe the proposed roles of these proteins in mediating Ca2+ signaling.

Main Methods:

  • Literature review of biochemical properties.
  • Analysis of proposed functional roles in Ca2+ signaling pathways.

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Main Results:

  • EF hand proteins like calmodulin and S100 proteins mediate Ca2+-dependent actions in the nucleus and cytoplasm.
  • Ca2+/phospholipid-binding proteins translocate to the plasma membrane upon increased cytosolic Ca2+.
  • Ca2+ storage proteins in the endoplasmic/sarcoplasmic reticulum regulate intracellular Ca2+ distribution.

Conclusions:

  • The complexity of Ca2+ signaling arises from the cooperative actions of diverse Ca2+-binding proteins.
  • Understanding these proteins is key to deciphering cellular responses to Ca2+ fluctuations.