Adjuvant antimicrobial therapy with renal calculus surgery

A randomized prospective study was done, comparing massive penicillin dosage (60 million units) to the recommended dose of ticarcillin (200 mg. per kg.) in the treatment of complicated urinary tract infections. A total of 50 patients with staghorn or multiple calculi who underwent anatrophic nephrolithotomy was entered into the study during a period of 14 months. Bacteriologic results were comparable. No significant toxicity from either massive penicillin or ticarcillin was observed.