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Thyroidal extracellular glutathione peroxidase: a potential regulator of thyroid-hormone synthesis
A F Howie1, S W Walker, B Akesson
1Cellular Endocrinology Unit, University Department of Clinical Biochemistry, Royal Infirmary, Edinburgh, U.K.
The Biochemical Journal
|June 15, 1995
Abstract:
Human thyrocytes were found to synthesize and secrete the selenoenzyme extracellular glutathione peroxidase (E-GPX), a process which was controlled by the Ca2+/phosphoinositol second-messenger cascade. The potential involvement of thyroidal E-GPX in the regulation of thyroid-hormone synthesis and in the protection of the thyrocyte from peroxidative damage is discussed.