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Updated: Aug 6, 2026
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Evidence for acute renal cortical vasoconstriction after uninephrectomy
D W Moskowitz1, K N Gillespie, S P Sutera
1Medicine Service, St. Louis VA Medical Center, MO 63106, USA.
Renal Failure
|November 1, 1996
Summary
Compensatory renal growth (CRG) signals are key to understanding chronic renal failure (CRF). Acute vasoconstriction in the renal cortex after unilateral nephrectomy (uniNx) may initiate CRG.
Area of Science:
- Nephrology
- Renal Physiology
- Cardiovascular Physiology
Background:
- Chronic renal failure (CRF) progression may involve intrinsic renal signals.
- The remnant nephron hypothesis links CRF to persistent compensatory renal growth (CRG).
- Understanding CRG initiation signals after unilateral nephrectomy (uniNx) is crucial for CRF insights.
Purpose of the Study:
- Investigate early signals initiating CRG in the renal cortex post-uniNx.
- Determine hemodynamic changes in the superficial renal cortex after uniNx.
- Elucidate the role of vasoconstriction in early CRG.
Main Methods:
- Utilized laser-Doppler flowmetry in adult male Sprague-Dawley rats.
- Monitored renal cortical blood velocity and blood volume continuously post-uniNx.
- Calculated renal cortical blood flow from velocity and volume data.
Main Results:
- Renal cortical blood velocity increased 22% within 5 min post-uniNx, sustained for 60 min.
- Renal cortical blood volume decreased throughout the observation period.
- Renal cortical blood flow showed a transient 14% increase at 5 min, then decreased.
Conclusions:
- Acute vasoconstriction in the superficial renal cortex occurs early after uniNx.
- This vasoconstriction may be an initiating event for compensatory renal growth (CRG).
- Findings offer insights into signals potentially driving chronic renal failure progression.
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