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Updated: Aug 2, 2026
07:32
Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta
Published on: February 7, 2018
[Papillary muscle rupture during subaortic membrane balloon dilatation]
Revista Espanola De Cardiologia
|February 1, 1996
Summary
Catheter-balloon dilation for discrete subaortic stenosis caused severe mitral regurgitation due to papillary muscle rupture. Careful guidewire and balloon positioning during left ventricular outflow tract angioplasty can prevent this complication.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Discrete subaortic stenosis is a congenital heart defect that can cause significant obstruction to left ventricular outflow.
- Catheter-balloon dilation is a less invasive treatment option for discrete subaortic stenosis.
- Mitral regurgitation is a potential complication of interventions affecting the left ventricular outflow tract.
Observation:
- A 37-year-old female experienced severe mitral regurgitation during catheter-balloon dilation for discrete subaortic stenosis.
- Emergency surgery revealed posteromedial papillary muscle rupture as the cause of the mitral regurgitation.
- Cineangiogram review showed balloon indentation at the site of the injured papillary muscle during inflation.
Findings:
- The posteromedial papillary muscle rupture was directly linked to the balloon inflation during the left ventricular outflow tract angioplasty.
- The indentation on the cineangiogram confirmed mechanical injury to the papillary muscle by the balloon device.
- Severe mitral regurgitation developed as a direct consequence of the papillary muscle rupture.
Implications:
- This case highlights a severe complication of left ventricular outflow tract angioplasty.
- Meticulous guidewire and balloon positioning are crucial to avoid papillary muscle injury during this procedure.
- Awareness of this risk can guide procedural modifications to improve patient safety in treating subaortic stenosis.
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