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Raynaud's phenomenon and digital necrosis induced by interferon-alpha
C Bachmeyer1, D Farge, E Gluckman
1Clinique des Maladies Cutanées, Hôpital Saint-Louis, Paris, France.
The British Journal of Dermatology
|September 1, 1996
Summary
Interferon-alpha treatment can cause Raynaud's phenomenon and digital necrosis. Stopping the drug led to symptom resolution, suggesting a drug-induced cause requiring medical attention.
Area of Science:
- Dermatology
- Pharmacology
- Vascular Medicine
Background:
- Interferon-alpha is a therapeutic cytokine used in treating various conditions.
- Raynaud's phenomenon is a condition characterized by exaggerated vasoconstriction of digits.
- Digital necrosis involves tissue death in fingers or toes.
Observation:
- Two patients treated with interferon-alpha developed Raynaud's phenomenon.
- These patients subsequently experienced multiple instances of digital necrosis.
- Vascular imaging showed diffuse distal narrowing, and histology confirmed ischemic necrosis without vasculitis.
Findings:
- Interferon-alpha was identified as the likely cause of Raynaud's phenomenon and digital necrosis.
- Symptoms resolved upon discontinuation of interferon-alpha therapy.
- Other potential causes for these conditions were excluded.
Implications:
- Clinicians should monitor patients on interferon-alpha for signs of Raynaud's phenomenon.
- Early recognition and withdrawal of interferon-alpha are crucial for managing drug-induced digital necrosis.
- This highlights the importance of considering iatrogenic causes for vascular complications.