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[Polycystic ovary and diazoxide. In vivo study]

J P Bercovici¹, P Monguillon, K Nahoul

¹Service d'Endocrinologie, Hôpital de la Cavale Blanche, Brest.

Annales D'Endocrinologie

|January 1, 1996

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Diazoxide treatment for hyperinsulinism in a PCOS patient reduced testosterone levels. However, it increased adrenal androgens like DHEAS and 3 alpha-adiol G, indicating complex hormonal shifts.

Area of Science:

Endocrinology
Reproductive Medicine

Background:

Polycystic Ovary Syndrome (PCOS) is often associated with hyperinsulinism and insulin resistance.
Hyperinsulinism can contribute to androgen excess in PCOS, exacerbating symptoms like hirsutism.

Observation:

Diazoxide, a hyperinsulinism suppressor, was administered to a young woman with PCOS and hirsutism.
Plasma androgen levels were monitored during the 30-day treatment period.

Findings:

Testosterone (T) and free testosterone (fT) initially decreased but remained below baseline, linked to reduced hyperinsulinism and increased TeBG.
Dehydroepiandrosterone sulfate (DHEAS) increased by 200% and 3 alpha-adiol G by threefold, indicating stimulated adrenal androgen secretion.
These hormonal modifications, particularly the rise in adrenal androgens, were consistent throughout diazoxide treatment.

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Implications:

Diazoxide's effect on androgens suggests a complex interplay between insulin suppression, adrenal activity, and ovarian androgen production in PCOS.
Understanding these hormonal dynamics is crucial for managing PCOS and its associated symptoms.
The study highlights the need for careful monitoring of adrenal androgens during hyperinsulinism treatment in PCOS patients.