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Calculation of RBE for normal tissue complications based on charged particle track structure
1Gesellschaft für Schwerionenforschung, Darmstadt, Germany.
Bulletin Du Cancer. Radiotherapie : Journal De La Societe Francaise Du Cancer : Organe De La Societe Francaise De Radiotherapie Oncologique
|January 1, 1996
Summary
A new model calculates relative biological effectiveness (RBE) for normal tissue complications from charged particle and neutron irradiation. This approach, based on cell survival models, shows RBE depends on the alpha/beta ratio, not absolute values, and is validated by animal experiments.
Area of Science:
- Radiation oncology
- Radiobiology
- Biophysics
Background:
- Calculating relative biological effectiveness (RBE) for normal tissue complications is crucial for radiation therapy planning.
- Existing models often require extensive data and may not be universally applicable.
- Charged particle and neutron irradiation offer therapeutic advantages but require accurate RBE determination.
Purpose of the Study:
- To present a novel model for calculating RBE for normal tissue complications.
- To extend a cell survival model for application to complex biological endpoints.
- To investigate the dependence of RBE on photon dose response parameters.
Main Methods:
- Extension of a pre-existing cell survival model.
- Application of the model to normal tissue complication data.
- Determination of alpha/beta ratios from fractionation experiments.
- Validation using animal experimental results.
Main Results:
- The model predicts RBE values are primarily determined by the alpha/beta ratio of the photon dose response curve.
- RBE values are expected to be nearly independent of the absolute alpha and beta values.
- Model predictions show good agreement with experimental results from animal studies.
Conclusions:
- The proposed model offers a robust method for calculating RBE for normal tissue complications.
- The model's applicability extends to complex biological endpoints, including those from charged particle and neutron irradiation.
- This approach simplifies RBE calculation by focusing on the alpha/beta ratio.